Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species.

@article{Xue2008CentralEI,
  title={Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species.},
  author={Baojian Xue and Yuanzi Zhao and Alan Kim Johnson and Meredith Hay},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 3},
  pages={H1025-H1032}
}
It has been shown that reactive oxygen species (ROS) contribute to the central effect of ANG II on blood pressure (BP). Recent studies have implicated an antihypertensive action of estrogen in ANG II-infused female mice. The present study used in vivo telemetry recording and in vitro living mouse brain slices to test the hypothesis that the central activation of estrogen receptors in male mice inhibits ANG II-induced hypertension via the modulation of the central ROS production. In male wild… CONTINUE READING

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