Central effects produced by injection of 48/80 into the cerebral ventricles of mice.

@article{Rocha1959CentralEP,
  title={Central effects produced by injection of 48/80 into the cerebral ventricles of mice.},
  author={elia da Rocha and M{\'a}rio Henrique Rocha Alves da Silva},
  journal={British journal of pharmacology and chemotherapy},
  year={1959},
  volume={14 2},
  pages={
          243-5
        }
}
Injections of 20 to 30 mug. of 48/80 into the cerebral ventricular spaces of mice produced a condition of motor excitement termed "delirium ambulatorium." This condition was aggravated by previous intraperitoneal injection of tranquillizers, atropine, and promethazine, not affected by previous injection of mepyramine and abolished by a previous injection of pentobarbitone. When an intraperitoneal injection of strychnine was followed by an intraventricular injection of 48/80, the strychnine… CONTINUE READING

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