Central effects of the anabolic steroid 17α methyltestosterone in female anxiety

  title={Central effects of the anabolic steroid 17$\alpha$ methyltestosterone in female anxiety},
  author={Juan Carlos Rivera-Arce and Lizannette Morales-Crespo and Noelia Vargas-Pinto and Kandy T Vel{\'a}zquez and Juan Carlos Jorge},
  journal={Pharmacology Biochemistry and Behavior},
7 Citations
Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors
Assessment of information to date on the importance of sex and its interaction with other environmental factors on affective behaviors in anabolic androgenic steroids suggests significant sex-specific differences in the impact of AAS on aggression, anxiety, and concomitant use of other abused substances.
Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: effects on anxiety behavior in postpartum and virgin female rats.
The results suggest that the impaired maternal behavior after BSTv infusion of yohimbine or idazoxan cannot both be readily explained by an increase in dams' anxiety, and that BSTv α2-autoreceptor modulation alone has little influence on anxiety-related behaviors in postpartum or diestrous rats.
The effects of intra-cerebral drug infusions on animals' unconditioned fear reactions: A systematic review
  • E. EnginD. Treit
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2008
Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex
The interaction with the NR2B-selective antagonist ifenprodil indicates that this NMDA receptor subunit may be involved in neurosteroid-induced NG108-15 cell detachment.
The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor
Anxiolytic-like Effect of Testosterone in Male Rats: GABAC Receptors Are Not Involved
The results of the present study showed that administration of testosterone induces anxiolytic-like behaviors in the rats and GABAC receptors possibly are not involved in the anxIOlytic effect of testosterone.


Treatment with an Anabolic-Androgenic Steroid Affects Anxiety-Related Behavior and Alters the Sensitivity of Cortical GABAA Receptors in the Rat
The putative psychotropic effect of the anabolic-androgenic steroid, testosterone propionate (TP), was determined in intact adult male rats after 1 or 2 weeks of continued exposure via subcutaneously implanted capsules and the agonist effects of reduced androgen metabolites at the GABAA receptor and the possible development of tolerance to these effects are discussed.
Modulation of affect after chronic exposure to the anabolic steroid 17alpha-methyltestosterone in adult mice.
Results show that systemic exposure to a single AAS modified social behaviors, whereas minimal effects on anxiety-related behaviors were observed according to sex.
CNS effects and abuse liability of anabolic-androgenic steroids.
  • S. Lukas
  • Psychology, Biology
    Annual review of pharmacology and toxicology
  • 1996
A better understanding of neuroactive steroids, improved methods for assessing AAS abuse, and a revised interpretation of drug-seeking behavior are needed to develop improved treatment strategies for this emerging health-related problem.
Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety
The results raise the possibility that in addition to 3 α,5α-P and 3α,5β-P, some of their endogenously occurring pregnanediol metabolites may also influence physiological processes related to anxiety via the GRC.
Dorsomedial hypothalamic GABA regulates anxiety in the social interaction test
Testosterone Rapidly Reduces Anxiety in Male House Mice (Mus musculus)
Eight experiments supported the hypotheses that reflexive testosterone release by male mice during sexual encounters reduces male anxiety and that this anxiolysis is mediated by the conversion of testosterone to neurosteroids that interact with GABA(A) receptors.
Posttraining androgens’ enhancement of cognitive performance is temporally distinct from androgens’ increases in affective behavior
  • C. FryeE. Lacey
  • Psychology, Biology
    Cognitive, affective & behavioral neuroscience
  • 2001
It is suggested that these androgens, when administered following training, can enhance cognitive performance in the tasks investigated 24 h later when androgen levels nadir, but overt changes in the affective behaviors examined occurred at the time of physiological concentrations 1 h but not 24 h following androgen administration.