Central effects of lithium in rats: lithium levels, body weight and water intake.

@article{Smith1983CentralEO,
  title={Central effects of lithium in rats: lithium levels, body weight and water intake.},
  author={Donald F. Smith and Amdi Amdisen},
  journal={Acta pharmacologica et toxicologica},
  year={1983},
  volume={52 2},
  pages={81-5}
}
Male rats received LiCl for one week either by continuous intracerebroventricular injection from osmotic minipumps or by oral administration in the diet. Control groups received corresponding treatment with NaCl. The intracerebroventricular lithium treatment produced relatively high lithium levels in brain regions (0.6-2.3 mmol/kg) and negligible lithium levels in plasma (less than 0.1 mmol/l) while the oral treatment produced moderate lithium levels in brain regions as well as in blood (0.5-0… CONTINUE READING