Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.

@article{Carai2002CentralEO,
  title={Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.},
  author={Mauro A. M. Carai and Giancarlo Colombo and Roberta Reali and Salvatore Serra and Ignazia Mocci and Maria Paola Castelli and Giorgio Cignarella and Gian Luigi Gessa},
  journal={European journal of pharmacology},
  year={2002},
  volume={441 3},
  pages={157-63}
}
The aliphatic alcohol 1,4-butanediol in converted into gamma-hydroxybutyric acid (GHB) via two enzymatic steps: first, it is oxidised by alcohol dehydrogenase in gamma-hydroxybutyraldehyde; second, the latter is transformed, likely by aldehyde dehydrogenase, into GHB. Initially, the present study compared the sedative/hypnotic effect of GHB and 1,4-butanediol, measured as loss of righting reflex. 1,4-Butanediol was more potent than GHB, presumably because of a more rapid penetration of the… CONTINUE READING