Central effects following repeated treatment with antidepressant drugs.

@article{Maj1984CentralEF,
  title={Central effects following repeated treatment with antidepressant drugs.},
  author={Jerzy Maj},
  journal={Polish journal of pharmacology and pharmacy},
  year={1984},
  volume={36 2-3},
  pages={
          87-99
        }
}
  • Jerzy Maj
  • Published in
    Polish journal of…
    1984
The review sums up the results of experiments in which there were studied central effects following repeated administration of various antidepressant drugs (AD) in rats and mice. A number of typical and atypical AD, except for selective inhibitors of 5-hydroxytryptamine (5-HT) uptake, potentiate the clonidine aggressiveness in mice (medicated by alpha 1-adrenoceptors). These results indicate that the repeated AD administration enhances responsiveness of central postsynaptic alpha 1… CONTINUE READING