Central dopaminergic transmission is selectively increased in the limbic system of rats chronically exposed to antidepressants.

@article{Montis1990CentralDT,
  title={Central dopaminergic transmission is selectively increased in the limbic system of rats chronically exposed to antidepressants.},
  author={G M De Montis and Paola Devoto and Gian Luigi Gessa and Daniela Meloni and Anna Porcella and Pierluigi Saba and Gino Serra and Alessandro Tagliamonte},
  journal={European journal of pharmacology},
  year={1990},
  volume={180 1},
  pages={31-5}
}
Repeated electroconvulsive shock (ECS) exposure produced a decrease of [3H]SCH 23390 binding sites and a reduced response of adenylate cyclase activity to dopamine D-1 receptor stimulation in the rat limbic area analogous to that previously observed in rats chronically treated with imipramine. These effects were completely prevented by the repeated administration of a small dose of alpha-methyl-p-tyrosine (alpha-MPT), associated with the tricyclic compound. Increased dopaminergic transmission… CONTINUE READING