Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats Characterization by the use of antagonists

@article{Fuller1984CentralDR,
  title={Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats Characterization by the use of antagonists},
  author={Ray W. Fuller and Harold D. Snoddy},
  journal={Neuropharmacology},
  year={1984},
  volume={23},
  pages={1389-1394}
}
Antagonism of Serotonin Agonist-Elicited Increases in Serum Corticosterone Concentration in Rats
Serum corticosterone and adrenocorticotropin (ACTH) concentrations are increased in rats by numerous direct-acting and indirect-acting serotonin receptor agonists. Antagonism of these increases by
Repeated treatment with antidepressant drugs and/or electroconvulsive shock (ECS) does not affect the quinpirole-induced elevation of the serum corticosterone concentration in rats
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The above results indicate that repeated treatment with antidepressant drugs and/or ECS does not affect the sensitivity of dopamine D2 receptors involved in the corticosterone response to quinpirole.
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Olanzapine is more potent in blocking the 5HT2A receptor than D1, D2, D3 and muscarinic receptors in vivo, consistent with its favorable clinical profiles.
Dopamine D1 and D2 dopamine receptors regulate immobilization stress-induced activation of the hypothalamus-pituitary-adrenal axis
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Dopamine, acting through both D1 and D2 receptors, exerts a stimulatory role on the activation of the HPA axis in response to a severe stressor.
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Methiothepin, a potent 5‐HT antagonist and dopamine antagonist, mimicked spiperone in causing a marked increase in striatal DOPAC in amfonelic acid‐treated rats, indicating that5‐HT antagonism is not involved in the lack of synergism of flumezapine and zotepine with amf Colonelic acid.
Dopamine receptor modulation of corticosterone secretion in neonatal and adult rats
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It is demonstrated that dopaminergic neurochemical control of the hypothalamus‐pituitary‐adrenal axis exists in four week old rats in contrast to previous studies which have shown opioid control to be absent at this age.
Oxaprotiline enantiomers stimulate ACTH and corticosterone secretion in the rat
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The results indicate that neither the NA system nor D2 and 5-HT receptors are involved in the hormonal response to the OXA enantiomers, and it cannot be excluded that both these enantiomer act as non-specific Stressors.
Effect of Naloxone on the Secretion of Corticosterone Induced by Gamma‐Hydroxybutyric Acid in Male Rats
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Neither dopaminergic nor serotoninergic systems intervened in the γ‐hydroxybutyrate‐stimulating effect on the hypothalamo‐hypophysial‐adrenocortical axis, suggesting independence from the GABAergic system.
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TLDR
The hypothesis that activation of brain dopaminergic receptors leads to increased serum corticosterone concentration in rats is strengthened, with haloperidol and domperidone shown to be capable of blocking peripheral (pituitary) dopamine receptors.
Elevation of serum corticosterone concentrations in rats by pergolide and other dopamine agonists.
TLDR
Spiperone and haloperidol, known dopamine antagonists, blocked the increase in serum corticosterone and partially antagonized quipazine's effect atdoses higher than those required to prevent the effect of pergolide.
Serum corticosterone elevation by pergolide in rats: prevention of tolerance development by spiperone
TLDR
Whether spiperone would prevent the development of tolerance to pergolide was determined and suggested to represent subsensitivity of dopaminergic receptors mediating the corticosterone response.
SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.
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Neurochemical Studies of the Mesolimbic Dopaminergic Pathway: [3H]Spiperone Labels Two Binding Sites in Homogenates of the Nucleus Accumbens of Rat Brain
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TLDR
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TLDR
It is reported here that one of these ergoline analogues, LY-141865 or ‘38, R = pro’21, stimulates the D-2 receptor in the intermediate lobe (IL) of the rat pituitary gland but does not interact with theD-1 receptor in carp retina.
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