Central depressant effects of N3-substituted 6-azauridines in mice.

  title={Central depressant effects of N3-substituted 6-azauridines in mice.},
  author={M. Koshigami and K. Watanabe and T. Kimura and I. Yamamoto},
  journal={Chemical & pharmaceutical bulletin},
  volume={39 10},
  • M. Koshigami, K. Watanabe, +1 author I. Yamamoto
  • Published 1991
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • Central depressant effects in mice of N3-substituted 6-azauridines (6-AzUd) (1) were examined by intracerebroventricular (i.c.v.) injection. Eleven derivatives including alkyl-, benzyl-, xylyl- and phenylethyl-substitution onto the N3-position of 1 were synthesized and their pharmacological effects were evaluated using hypnotic activity, locomotor activity, motor incoordination and pentobarbital-induced sleep prolongation as indices. Six of 12 compounds showed the hypnotic activity. At a dose… CONTINUE READING
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