Corpus ID: 21052121

Central depressant activities of N3-allyluridine and N3-allylthymidine.

@article{Yamamoto1986CentralDA,
  title={Central depressant activities of N3-allyluridine and N3-allylthymidine.},
  author={I. Yamamoto and T. Kimura and Y. Tateoka and K. Watanabe and I. Ho},
  journal={Research communications in chemical pathology and pharmacology},
  year={1986},
  volume={52 3},
  pages={
          321-32
        }
}
  • I. Yamamoto, T. Kimura, +2 authors I. Ho
  • Published 1986
  • Chemistry, Medicine
  • Research communications in chemical pathology and pharmacology
  • The pharmacological effects of N3-allyluridine (N3-AUd) and N3-allylthymidine (N3-ATd) on the central nervous system (CNS) were examined by intracerebroventricular (i.c.v.) administration in mice. Pentobarbital (PB)-induced sleep, diazepam (DZ)-induced motor incoordination and spontaneous activity were used as three indices of pharmacological tests. N3-AUd and N3-ATd as well as uridine (Ud) and thymidine (Td); 0.9 mg/mouse, i.c.v., were found to potentiate PB-induced sleep, and their effects… CONTINUE READING
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