Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype.

@article{Camerino2012CentralDO,
  title={Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype.},
  author={Claudia Camerino and Majd Zayzafoon and Michal Rymaszewski and Judith A Heiny and M. Garc{\'i}a de los Rios and Peter V. Hauschka},
  journal={Endocrinology},
  year={2012},
  volume={153 11},
  pages={5394-405}
}
Brain-derived neurotrophic factor (BDNF) plays important roles in neuronal differentiation/survival, the regulation of food intake, and the pathobiology of obesity and type 2 diabetes mellitus. BDNF and its receptor are expressed in osteoblasts and chondrocyte. BDNF in vitro has a positive effect on bone; whether central BDNF affects bone mass in vivo is not known. We therefore examined bone mass and energy use in brain-targeted BDNF conditional knockout mice (Bdnf(2lox/2lox)/93). The deletion… CONTINUE READING

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