Central cholinergic depression reduces MAC for isoflurane in rats.

  title={Central cholinergic depression reduces MAC for isoflurane in rats.},
  author={J R Zucker},
  journal={Anesthesia and analgesia},
  volume={72 6},
  • J R Zucker
  • Published 1991 in Anesthesia and analgesia
The role of central nervous system cholinergic neuromechanisms during inhalation (isoflurane) anesthesia was evaluated by measuring the minimum alveolar concentration (MAC) in rats before and after selective modulation of cholinergic neurotransmission in the brain. Cholinergic neurotransmission was depressed by reducing synaptic levels of acetylcholine with intracerebroventricular (ICV) injection of the selective anticholinergic hemicholinium-3 and with ICV injection of the presynaptic… CONTINUE READING


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