Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis

@inproceedings{Ji2014CentralCA,
  title={Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis},
  author={Hong Ji and Mohammad Fazle Rabbi and Benoit Labis and Valentin Pavlov and Kevin J Tracey and Jean-Eric Ghia},
  booktitle={Mucosal Immunology},
  year={2014}
}
The cholinergic anti-inflammatory pathway is an efferent vagus nerve–based mechanism that regulates immune responses and cytokine production through α7 nicotinic acetylcholine receptor (α7nAChR) signaling. Decreased efferent vagus nerve activity is observed in inflammatory bowel disease. We determined whether central activation of this pathway alters inflammation in mice with colitis and the mediating role of a vagus nerve-to-spleen circuit and α7nAChR signaling. Two experimental models of… CONTINUE READING

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