Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterhyperpolarization in supraoptic oxytocin neurons.

@article{Teruyama2008CentralBO,
  title={Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterhyperpolarization in supraoptic oxytocin neurons.},
  author={Ryoichi Teruyama and David L. Lipschitz and Liangsu Wang and Gina Ramoz and William R. Crowley and Steven L. Bealer and William E. Armstrong},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={295 5},
  pages={E1167-71}
}
The neurohypophysial hormone oxytocin (OT), synthesized in magnocellular paraventricular (PVN) and supraoptic (SON) nuclei, is well known for its effects in lactation. Our previous studies showed that central OT receptor (OTR) binding is increased during gestation and that blockade of central OTRs, specifically during mid-late gestation, causes a delay in OT release during suckling and reduces weight gain in pups, suggesting decreased milk delivery. In the present study, we tested whether… CONTINUE READING

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