Central beta- and alpha-adrenolytic activities of adimolol.

  title={Central beta- and alpha-adrenolytic activities of adimolol.},
  author={Jerzy Maj and Violetta Klimek and Aneta Lewandowska and Magdalena Zazula},
  journal={Polish journal of pharmacology and pharmacy},
  volume={39 1},
The central adrenergic blocking activity of adimolol (ADL) was studied in rats and mice in the tests which can differentiate beta-, alpha 1-, and alpha 2-adrenolytic effects. Clenbuterol- and salbutamol-induced sedation in rats (open field test) and clenbuterol-induced hyperthermia (at high ambient temperature) were antagonized by low doses of ADL (0.1-1.0 mg/kg ip). ADL (10 mg/kg ip) attenuated the clonidine-induced aggression in mice, and its higher doses (20 and 40 mg/kg ip) depressed the… CONTINUE READING