Central application of IGF-1 postpones time of vaginal opening in normally fed, but not in food-restricted rats.

Abstract

BACKGROUND/AIMS Central but also peripheral IGF-1 is suggested to play a role in the initiation of puberty as it directly affects GnRH synthesis and release. A possible intermediate in the effects of IGF-1 on puberty might be the adiposity-signaling hormone leptin, whose plasma levels are decreased in food-restricted (FR) rats. METHODS IGF-1 was… (More)

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@article{Zeinoaldini2006CentralAO, title={Central application of IGF-1 postpones time of vaginal opening in normally fed, but not in food-restricted rats.}, author={Saeed Zeinoaldini and Jerome M. Swarts and Bert J. M. van de Heijning}, journal={Hormone research}, year={2006}, volume={66 4}, pages={169-74} }