Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors.

@article{Pacheco2014CentralAI,
  title={Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors.},
  author={Daniela da Fonseca Pacheco and Thiago Roberto Lima Romero and Igor Dimitri Gama Duarte},
  journal={Brain research},
  year={2014},
  volume={1562},
  pages={69-75}
}
It is generally believed that NMDA receptor antagonism accounts for most of the anesthetic and analgesic effects of ketamine, however, it interacts at multiple sites in the central nervous system, including NMDA and non-NMDA glutamate receptors, nicotinic and muscarinic cholinergic receptors, and adrenergic and opioid receptors. Interestingly, it was shown that at supraspinal sites, ketamine interacts with the μ-opioid system and causes supraspinal antinociception. In this study, we… CONTINUE READING

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