Central angiotensin II-induced responses in spontaneously hypertensive rats.

  title={Central angiotensin II-induced responses in spontaneously hypertensive rats.},
  author={William E. Hoffman and Michael Ian Phillips and Phillip G. Schmid},
  journal={The American journal of physiology},
  volume={232 4},
The brain isorenin angiotensin system has been implicated in the development of spontaneous hypertension by several investigators. The experiments reported here were designed to test the responsiveness of unanesthetized spontaneous hypertensive (SH) rats to intracerebroventricular angiotensin II injections compared to Wistar-Kyoto (WK) normotensive controls. The results indicate that there is no difference between SH and WK animals in drinking responses or antidiuretic hormone release to… CONTINUE READING

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