Central angiotensin II controls alcohol consumption via its AT1 receptor.

  title={Central angiotensin II controls alcohol consumption via its AT1 receptor.},
  author={Bjoern Maul and Winfried Krause and Kristin Pankow and Matthias Becker and Florian Gembardt and Natalia Alenina and T Walther and Michael Bader and Wolf-Eberhard Siems},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={19 11},
Pharmacological and genetic manipulations of the renin-angiotensin system (RAS) have been found to alter the voluntary consumption of alcohol. Here we characterize the role of central angiotensin II (Ang II) in alcohol intake first by using transgenic rats that express an antisense RNA against angiotensinogen and consequently have reduced Ang II levels exclusively in the central nervous system [TGR(ASrAOGEN)680]. These rats consumed markedly less alcohol in comparison to their wild-type… CONTINUE READING