Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus.

@article{ElHaddad2005CentralAI,
  title={Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus.},
  author={Mostafa A El-Haddad and Yaser Mahmud Ismail and Dave Gayle and Michael G. Ross},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={288 4},
  pages={R1014-20}
}
Swallowed volumes in the fetus are greater than adult values (per body weight) and serve to regulate amniotic fluid volume. Central ANG II stimulates swallowing, and nonspecific ANG II receptor antagonists inhibit both spontaneous and ANG II-stimulated swallowing. In the adult rat, AT1 receptors mediate both stimulated drinking and pressor activities, while the role of AT2 receptors is controversial. As fetal brain contains increased ANG II receptors compared with the adult brain, we sought to… CONTINUE READING

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