Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders

@inproceedings{McGuire2015CentralAP,
  title={Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders},
  author={Jennifer L. McGuire and Alexander J Gill and Steven D. Douglas and Dennis L Kolson},
  booktitle={Journal of NeuroVirology},
  year={2015}
}
HIV-associated neurocognitive disorders (HAND) affect up to 50 % of HIV-infected adults, independently predict HIV morbidity/mortality, and are associated with neuronal damage and monocyte activation. Cerebrospinal fluid (CSF) neurofilament subunits (NFL, pNFH) are sensitive surrogate markers of neuronal damage in several neurodegenerative diseases. In HIV, CSF NFL is elevated in individuals with and without cognitive impairment, suggesting early/persistent neuronal injury during HIV infection… CONTINUE READING
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