Central and peripheral glucocorticoid receptors are involved in the plasma cortisol response to an acute stressor in rainbow trout.

@article{Alderman2012CentralAP,
  title={Central and peripheral glucocorticoid receptors are involved in the plasma cortisol response to an acute stressor in rainbow trout.},
  author={S. Alderman and Alison McGuire and N. Bernier and M. Vijayan},
  journal={General and comparative endocrinology},
  year={2012},
  volume={176 1},
  pages={
          79-85
        }
}
  • S. Alderman, Alison McGuire, +1 author M. Vijayan
  • Published 2012
  • Medicine, Biology
  • General and comparative endocrinology
  • Cortisol, the primary circulating corticosteroid in teleosts, is elevated during stress following activation of the hypothalamus-pituitary-interrenal (HPI) axis. Cortisol exerts genomic effects on target tissues in part by activating glucocorticoid receptors (GR). Despite a well-established negative feedback loop involved in plasma cortisol regulation, the role of GR in the functioning of the HPI axis during stress in fish is still unclear. We used mifepristone (a GR antagonist) to suppress GR… CONTINUE READING
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