Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor.

@article{Jin1996CentralAP,
  title={Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor.},
  author={Jianguo Jin and L G D'alecy},
  journal={Journal of cardiovascular pharmacology},
  year={1996},
  volume={28 3},
  pages={
          439-46
        }
}
We tested the hypothesis that the endogenous nitric oxide synthetase (NOS) inhibitor, asymmetric dimethylarginine (ADMA), regulates cardiovascular function by central mechanisms. In in vivo studies, rats received intracerebroventricular (i.c.v.) injection of isotonic saline, ADMA (1 mg), l-arginine (3 mg), and N omega-nitro-l-arginine methylester (l-NAME, 1 mg). Baroreflex function was then assessed by intravenous (i.v.) injection of phenylephrine. Central application of exogenous NOS inhibitor… CONTINUE READING
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