Central and peripheral contributions to muscle fatigue in humans during sustained maximal effort

@article{KentBraun1999CentralAP,
  title={Central and peripheral contributions to muscle fatigue in humans during sustained maximal effort},
  author={Jane A. Kent‐Braun},
  journal={European Journal of Applied Physiology and Occupational Physiology},
  year={1999},
  volume={80},
  pages={57-63}
}
  • J. Kent‐Braun
  • Published 1 June 1999
  • Biology
  • European Journal of Applied Physiology and Occupational Physiology
Abstract The purpose of this study was to estimate the relative contributions of central and peripheral factors to the development of human muscle fatigue. Nine healthy subjects [five male, four female; age = 30 (2) years, mean (SE)] sustained a maximum voluntary isometric contraction (MVC) of the ankle dorsiflexor muscles for 4 min. Fatigue was quantitated as the fall in MVC. Three measures of central activation and one measure of peripheral activation (compound muscle action potential, CMAP… 
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382 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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382 Citations

Relative contributions of central and peripheral factors to fatigue during a maximal sustained effort
TLDR
The decline of MFCV indicated that peripheral fatigue increased predominantly during the first half of the contraction and stayed at a constant level during the latter part, in contrast, central fatigue mainly induced a force decrease in the second part of the contractions.
Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise.
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The results suggest that the mechanisms of fatigue vary with age and gender, regardless of whether differences in the magnitude of fatigue are observed, and a greater reliance on nonoxidative sources of ATP in young compared with older subjects and in men compared with women.
CENTRAL AND PERIPHERAL FATIGUE DURING SUSTAINED MAXIMAL VOLUNTARY CONTRACTIONS IN TRAINED AND UNTRAINED HUMAN SUBJECTS
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It is concluded that expression of central and peripheral fatigue is affected by resistance training.
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The greater alterations in the contractile properties observed during the CON contractions indicate that intracellular Ca2+‐controlled excitation–contraction (E–C) coupling processes, possibly associated with a higher energy requirement, are affected to a much greater degree than during ECC contractions.
Central fatigue during isometric exercise in amyotrophic lateral sclerosis
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Patients with ALS had less intramuscular phosphocreatine depletion and less fatigue of stimulated tetanic force during exercise compared to control, demonstrating a major contribution of central factors to muscle fatigue in ALS.
The cross-over effect of neuromuscular fatigue in the plantar flexors
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The present study evaluating neuromuscular fatigue in the plantar flexors found a cross-over effect to the contralateral, non-exercised leg, and peripheral mechanisms seem mainly to have attributed to the decrease in MVC force in the exercised leg, while central mechanisms seems less to contribute.
Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
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It is suggested that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level.
Central fatigue after cycling evaluated using peripheral magnetic stimulation.
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Results clearly demonstrate that trained cyclists experience significant central fatigue during prolonged cycling, and suggest that PMS may be a better technique for identifying central fatigue than the traditionally used interpolated twitch technique.
Central and peripheral contributions to physical and electrical fatigue
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Investigating central and peripheral contributions to muscle fatigue, immediately and 20 minutes after physical and electrical fatigue in 25 healthy male volunteers found central inhibition was recorded after physical fatigue while some cortical facilitation was proofed after electrical fatigue.
Neuromuscular responses to mild-muscle damaging eccentric exercise in a low glycogen state.
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  • Biology
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  • 2015
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