Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats

To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema. Male Wistar rats were used. Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg−1) was assessed using a paw edema model. Secondly, different doses of maprotiline were administrated intracerebroventricularly… CONTINUE READING

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