Corpus ID: 31353655

Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400.

@article{Barber1994CentralAP,
  title={Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400.},
  author={A. Barber and G. Bartoszyk and H. Greiner and F. Mauler and R. Murray and C. Seyfried and M. Simon and R. Gottschlich and J. Harting and I. Lues},
  journal={British journal of pharmacology},
  year={1994},
  volume={111 3},
  pages={
          843-51
        }
}
1. The pharmacological characteristics of the kappa-opioid receptor agonist, EMD 60400, have been investigated, with particular reference to its central and peripheral sites of action and its ability to influence nociception. The kappa agonists ICI 197067 and ICI 204448 were tested for purposes of comparison. 2. EMD 60400 and ICI 197067 bind with high affinity (IC50 values of 2.8 and 1.5 nM, respectively) and high selectivity to kappa-opioid receptors. ICI 204448 has a lower binding affinity… Expand