Central and Peripheral Irisin Differentially Regulate Blood Pressure

@article{Zhang2015CentralAP,
  title={Central and Peripheral Irisin Differentially Regulate Blood Pressure},
  author={Weizhen Zhang and Lin Chang and Chao Zhang and Ruthann Zhang and Ziru Li and Biaoxin Chai and Jiyao Li and Eugene Y.-X. Chen and M. N. C. Mulholland},
  journal={Cardiovascular Drugs and Therapy},
  year={2015},
  volume={29},
  pages={121-127}
}
IntroductionIrisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown.PurposeTo explore the effects of central and peripheral irisin on cardiovascular functions.MethodsIrisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and… CONTINUE READING
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