Central administration of resveratrol improves diet-induced diabetes.

  title={Central administration of resveratrol improves diet-induced diabetes.},
  author={Giorgio Ramadori and Laurent Gautron and Teppei Fujikawa and Claudia R. Vianna and Joel K Elmquist and Roberto Coppari},
  volume={150 12},
Resveratrol is a natural polyphenolic compound that activates nicotinamide adenosine dinucleotide-dependent deacetylase SIRT1. Resveratrol has recently been shown to exert potent antidiabetic actions when orally delivered to animal models of type 2 diabetes. However, the tissue(s) mediating these beneficial effects is unknown. Because SIRT1 is expressed in central nervous system (CNS) neurons known to control glucose and insulin homeostasis, we hypothesized that resveratrol antidiabetic effects… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 51 references

Hepatic glucose metabolism in humans--its role in health and disease.

Best practice & research. Clinical endocrinology & metabolism • 2003
View 15 Excerpts
Highly Influenced

CNS Resveratrol Administration Improves Diabetes Endocrinology

GJ Morton, DE Cummings, DG Baskin, GS Barsh, MW RamadoriSchwartz
For personal use only. No other uses without permission. . All rights reserved • 2009
View 1 Excerpt

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt

Brain SIRT1: anatomical distribution and regulation by energy availability.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 2 Excerpts

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