Central administration of resveratrol improves diet-induced diabetes.

@article{Ramadori2009CentralAO,
  title={Central administration of resveratrol improves diet-induced diabetes.},
  author={Giorgio Ramadori and Laurent Gautron and Teppei Fujikawa and Claudia R. Vianna and Joel K Elmquist and Roberto Coppari},
  journal={Endocrinology},
  year={2009},
  volume={150 12},
  pages={5326-33}
}
Resveratrol is a natural polyphenolic compound that activates nicotinamide adenosine dinucleotide-dependent deacetylase SIRT1. Resveratrol has recently been shown to exert potent antidiabetic actions when orally delivered to animal models of type 2 diabetes. However, the tissue(s) mediating these beneficial effects is unknown. Because SIRT1 is expressed in central nervous system (CNS) neurons known to control glucose and insulin homeostasis, we hypothesized that resveratrol antidiabetic effects… CONTINUE READING

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