Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats.

@article{Lenczowski1999CentralAO,
  title={Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats.},
  author={M. J. P. Lenczowski and R-M Bluth{\'e} and Joachim Roth and G S Rees and David A Rushforth and A-M van Dam and Fred J. H. Tilders and Robert Dantzer and Nancy J. Rothwell and Giamal N. Luheshi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1999},
  volume={276 3},
  pages={R652-R658}
}
Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6 (rrIL-6) on the induction of hypothalamic-pituitary-adrenal (HPA) activity, fever, social investigatory behavior, and immobility. After… CONTINUE READING