Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques.

@article{TangChristensen1999CentralAO,
  title={Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques.},
  author={Mads Tang-Christensen and P. Havel and Ruth Rose Jacobs and Philip Just Larsen and Judy L Cameron},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 2},
  pages={711-7}
}
The present study was performed to determine the effects of central administration of leptin on food intake and sympathetic nervous system activity in a nonrodent species, the rhesus monkey. Peripheral administration of leptin at doses (1 and 3 microg/kg, s.c.) that produced increments of circulating leptin concentrations within a physiological range did not inhibit food intake over the subsequent 3 days. In contrast, leptin (1 microg/kg, intracerebroventricularly) had no acute effect on food… CONTINUE READING