Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence.

@article{Hansson2011CentralAO,
  title={Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence.},
  author={Caroline Hansson and David Haage and Magdalena Taube and Emil Egecioglu and Nicolas Salom{\'e} and Suzanne L. Dickson},
  journal={Neuroscience},
  year={2011},
  volume={180},
  pages={201-11}
}
The orexigenic and pro-obesity hormone ghrelin targets key hypothalamic and mesolimbic circuits involved in energy balance, appetite and reward. Given that such circuits are closely integrated with those regulating mood and cognition, we sought to determine whether chronic (>2 weeks) CNS exposure to ghrelin alters anxiety- and depression-like behaviour in rats as well as some physiological correlates. Rats bearing chronically implanted i.c.v. catheters were treated with ghrelin (10 μg/d) or… CONTINUE READING