Central activation of the trigeminovascular pathway in the cat is inhibited by dihydroergotamine. A c-Fos and electrophysiological study.

@article{Hoskin1996CentralAO,
  title={Central activation of the trigeminovascular pathway in the cat is inhibited by dihydroergotamine. A c-Fos and electrophysiological study.},
  author={Karen Lisa Hoskin and Holger Kaube and Peter J Goadsby},
  journal={Brain : a journal of neurology},
  year={1996},
  volume={119 ( Pt 1)},
  pages={249-56}
}
Recent studies have delineated a clear role for the trigeminal innervation of pain-sensitive intracranial structures in the pathophysiology of migraine. The development of new compounds for the treatment of the acute attack of migraine has led to a greater understanding of serotonin (5-hydroxytryptamine; 5HT) receptor diversity. The ergot alkaloids have been used in the treatment of acute attacks of migraine for many years and parenteral administration of dihydroergotamine (DHE) can be a useful… CONTINUE READING
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