Central action of sigma receptor ligand, JO 1784, to suppress CRF-induced inhibition of gastric function in conscious rats.

Abstract

The central interaction between the sigma receptor ligand, JO 1784, and corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion and emptying was investigated in conscious rats. Intracisternal (i.c.) injection of CRF (5 micrograms) inhibited by 95% gastric acid secretion. JO 1784 (0.05-0.5 micrograms) given i.c. immediately before i.c. injection of CRF partially reversed CRF antisecretory action whereas JO 1784 (5 micrograms) given i.v. had no effect. CRF (0.6 micrograms i.c.)-induced 83% inhibition of gastric emptying was reversed by 45% by JO 1784 (5 micrograms i.c.). JO 1784 (5-50 micrograms i.c.) did not influence basal gastric function. These data demonstrate a centrally mediated antagonistic action of the sigma receptor ligand, JO 1784, on i.c. CRF-induced inhibition of gastric function.

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@article{Yoneda1992CentralAO, title={Central action of sigma receptor ligand, JO 1784, to suppress CRF-induced inhibition of gastric function in conscious rats.}, author={Masato Yoneda and Jean Louis Junien and Yvette F. Tach{\'e}}, journal={European journal of pharmacology}, year={1992}, volume={223 2-3}, pages={197-9} }