Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage

@article{Yamamoto2019CentralAO,
  title={Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage},
  author={Shuzo Yamamoto and Tatsushi Mutoh and Kazumasu Sasaki and Tomoko Mutoh and Yasuyuki Taki},
  journal={Brain Research Bulletin},
  year={2019},
  volume={144},
  pages={85-91}
}
Early brain injury and related cardiac consequences play a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). We reported that rapamycin exerts neuroprotection against cortical hypoxia early after SAH, but its mechanism is poorly understood. This in vivo study aimed to determine the potential role of the transcription factor STAT3 in the rapamycin-mediated neuroprotection in a mouse model of SAH. Forty C57BL/6 N mice were treated with an intracerebroventricular injection… CONTINUE READING