Corpus ID: 25598252

Central action of mepiprazole.

  title={Central action of mepiprazole.},
  author={Jerzy G. Maj and M. Sypniewska},
  journal={Polish journal of pharmacology and pharmacy},
  volume={32 4},
  • J. Maj, M. Sypniewska
  • Published 1980
  • Chemistry, Medicine
  • Polish journal of pharmacology and pharmacy
Mepiprazole, a phenylpiperazine derivative, strongly antagonizes the behavioral syndromes evolved by 5-hydroxytrypotophan. The drug did not affect the serotonin neurons in the preparation of flexor reflex of the hind paw of the spinal rat: in higher doses it depressed the reflex showing noradrenolytic properties. Mepiprazole antagonized the fenfluramine-induced hyperthermia, depressed spontaneous locomotor activity, produce hypothermia and was inactive in the despair test. The results suggest… Expand
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