Central TNF-alpha elevates blood pressure and sensitizes to central pressor action of angiotensin II in the infarcted rats.

@article{era2008CentralTE,
  title={Central TNF-alpha elevates blood pressure and sensitizes to central pressor action of angiotensin II in the infarcted rats.},
  author={Tymoteusz Żera and Marcin Ufnal and E Szczepańska-sadowska},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2008},
  volume={59 Suppl 8},
  pages={117-21}
}
In patients with chronic heart failure (CHF) concentration of TNF-alpha is elevated. Enhanced synthesis of TNF-alpha was also found in the hypothalamus of rats shortly after induction of the myocardial infarct. Available evidence indicates that TNF-alpha increases sympathetic activity and enhances function of the renin-angiotensin-aldosterone system in… CONTINUE READING