Central Role of GABA in Neuron–Glia Interactions

@article{VlezFort2012CentralRO,
  title={Central Role of GABA in Neuron–Glia Interactions},
  author={Mateo V{\'e}lez-Fort and Etienne Audinat and Mar{\'i}a Cecilia Angulo},
  journal={The Neuroscientist},
  year={2012},
  volume={18},
  pages={237 - 250}
}
The major types of glial cells—astrocytes, microglia, and cells of the oligodendroglial lineage—are known to express functional metabotropic and ionotropic GABA receptors. Neuronal signaling mechanisms allowing for the activation of these receptors in glia are probably as complex as those described among neurons and involve synaptic and extrasynaptic transmission modes. In addition, astrocytes can signal back to neurons by releasing GABA, probably through unconventional nonvesicular mechanisms… CONTINUE READING

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