Central Pontine Myelinolysis

@article{Lampl2002CentralPM,
  title={Central Pontine Myelinolysis},
  author={C. Lampl and K. Yazdi},
  journal={European Neurology},
  year={2002},
  volume={47},
  pages={3 - 10}
}
Central pontine myelinolysis (CPM) is a demyelinating disease of the pons often associated with demyelination of other areas of the central nervous system (CNS). The term ‘osmotic demyelinization syndrome’ is used for pontine and extrapontine myelinolysis. In this paper, we are concerned with CPM although the extrapontine one is based on the same pathogenesis. Both share the diagnostic methods, and their prevention and therapy are the same. The etiology and pathogenesis of this disorder are… Expand
Central pontine and extrapontine myelinolysis
TLDR
Whenever a patient who is gravely ill with alcoholism and malnutrition or a systemic medical disease develops confusion, quadriplegia, pseudobulbar palsy, and pseudocoma over a period of several days, one is supposed to have a high index of suspicion for central pontine myelinolysis. Expand
Central Pontine Myelinolysis in a Patient Admitted for Alcohol Withdrawal
TLDR
The case of a normonatremic, alcoholic man who presented with a combination of dementia, cerebellar findings, and resting tremor is discussed, discussing the pathophysiology, differential diagnosis, and management of central pontine myelinolysis. Expand
Can central pontine myelinolysis be prevented through non-rapid serum sodium correction?
TLDR
A 55-year-old male patient with a history of alcohol abuse who presented with decreased levels of consciousness and a very conservative correction schedule was applied resulted in the development of central pontine myelinolysis, a rare neurological disorder characterized by a symmetric, demyelinating lesion of the central pons. Expand
Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction
TLDR
It is suggested that acute hepatic dysfunction may play an important role in the development of central pontine myelinolysis and extrapontineMyelinolyssis. Expand
[A case of central pontine and extrapontine myelinolysis, without hyponatremia, during alcohol withdrawal with favorable outcome].
TLDR
Central pontine and extra-pontine myelinolysis is a rare neurological disorder that should be considered in the setting of any unexplained neurological symptoms during the course of alcohol withdrawal or for any patient with chronic alcohol abuse, as promptly as possible, given the potentially fatal outcome. Expand
Central Pontine Myelinolysis in Alcoholism
TLDR
A better understanding of the ODS paradigm should aid in the development of new causal therapeutic approaches and effective preventive strategies in chronic alcoholics with this condition. Expand
Pontine Myelinolysis Caused by Hypovolemic Hypernatremia
TLDR
A case of the disease secondary to the occurrence of hypovolemic acute hypernatremia in a patient with a hematological malignancy under treatment, who was on chronic treatment with thiazide diuretics and who presented with other electrolyte disturbances as risk factors for the development of pontine myelinolysis is described. Expand
Rare association of central pontine myelinolysis with infantile tremor syndrome
TLDR
All the signs and symtoms of tremor improved after treatment with the World Health Organization (WHO) protocol for protein energy malnutrition (PEM) and administration of propranolol without any side effects. Expand
Asymptomatic Central Pontine Myelinolysis: A Case Report
TLDR
Although this patient did not demonstrate any neurological deficits, the fact that there were changes seen on MRI should caution physicians in aggressively treating hyponatremia, and if there is a decision to treat, then fluid restriction and reversal of precipitating factors should be used initially, unless there is concern for hypovolemia. Expand
Central pontine myelinolysis: case series and review.
TLDR
CPM and ODS are rare demyelinating diseases of the pons and extrapontine sites and Prompt diagnosis and management of associated complications are essential for favorable clinical outcomes. Expand
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TLDR
Current theories about etiology and pathogenesis of CPM are reviewed with special reference to the syndrome of inappropriate secretion of the antidiuretic hormone (IADH). Expand
Treatment of central pontine myelinolysis with therapeutic plasmapheresis
TLDR
Therapeutic plasmapheresis may reduce high-molecular myelinotoxic substances and therefore lead to clinical improvement in patients with CPM, and should be considered as a safe and effective method to improve the clinical outcome. Expand
Central pontine myelinolysis.
TLDR
Three additional patients with CPM have recently been studied at this institution, two of whom were found during the routine gross neuropathological examination and the other case was found after the authors had directed their search. Expand
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TLDR
Investigation of the molecular basis of the demyelinating process and the adaptive responses of the brain to dysosmolar challenge has allowed for the refinement of standard treatments and has made the osmotic Demyelination syndrome a treatable condition with a better than expected prognosis. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It is reasonable that the incidence of comparatively mild forms of CPM as well as extrapontine manifestations are more frequent than hitherto assumed and the clinical outcome of the syndrome is better than expected from earlier fatal case reports and is quite independent of the extent of the lesion as it appears with brain imaging methods. Expand
Recovery From Probable Central Pontine Myelinolysis Associated With Addison's Disease
TLDR
The first reported case of concurrent CPM and Addison's disease is described herein, and the clinical dilemma of proper treatment of severe hyponatremia is exemplified by this case. Expand
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