Central Opioid Receptors Differentially Regulate the Nalmefene-Induced Suppression of Ethanol- and Saccharin-Reinforced Behaviors in Alcohol-Preferring (P) Rats

@article{June2004CentralOR,
  title={Central Opioid Receptors Differentially Regulate the Nalmefene-Induced Suppression of Ethanol- and Saccharin-Reinforced Behaviors in Alcohol-Preferring (P) Rats},
  author={H. June and R. Cummings and William J. A. Eiler and K. L. Foster and P. F. McKay and Regat Seyoum and Marin Garcia and S. McCane and C. Grey and Stephanie E Hawkins and D. Mason},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={285-299}
}
The exact opioid-sensitive receptors participating in EtOH-seeking behaviors remains unclear. Previous studies have reported higher densities of μ-opioid receptor binding in the nucleus accumbens (NACC) of P relative to NP rats; however, no differences were seen in δ-receptor binding. In contrast to the NACC, substantially lower levels of μ-receptor binding have been observed in the ventral tegmental area (VTA) of both P and NP rats, albeit no line differences have been observed. In the present… Expand
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