Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential

  title={Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential},
  author={Maria Novella Romanelli and Paola Gratteri and Luca Guandalini and Elisabetta Martini and Claudia Bonaccini and Fulvio Gualtieri},
The growing interest in nicotinic receptors, because of their wide expression in neuronal and non‐neuronal tissues and their involvement in several important CNS pathologies, has stimulated the synthesis of a high number of ligands able to modulate their function. These membrane proteins appear to be highly heterogeneous, and still only incomplete information is available on their structure, subunit composition, and stoichiometry. This is due to the lack of selective ligands to study the role… 
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