Central Nervous System Delivery of the Antipsychotic Olanzapine Induces Hepatic Insulin Resistance

@inproceedings{Martins2010CentralNS,
  title={Central Nervous System Delivery of the Antipsychotic Olanzapine Induces Hepatic Insulin Resistance},
  author={Paulo J.F. Martins and Michael J. Haas and Silvana Obici},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Olanzapine (OLZ) is an atypical antipsychotic whose clinical efficacy is hampered by side effects including weight gain and diabetes. Recent evidence shows that OLZ alters insulin sensitivity independent of changes in body weight and composition. The present study addresses whether OLZ-induced insulin resistance is driven by its central actions. RESEARCH DESIGN AND METHODS Sprague-Dawley rats received an intravenous (OLZ-IV group) or intracerebroventricular (OLZ-ICV group) infusion… CONTINUE READING
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