Central Nervous System Chemokine mRNA Accumulation Follows Initial Leukocyte Entry at the Onset of Acute Murine Experimental Autoimmune Encephalomyelitis

@article{Glabinski1995CentralNS,
  title={Central Nervous System Chemokine mRNA Accumulation Follows Initial Leukocyte Entry at the Onset of Acute Murine Experimental Autoimmune Encephalomyelitis},
  author={A. R. Glabinski and M. Tani and V. K. Tuohy and R. J. Tuthill and R. M. Ransohoff},
  journal={Brain, Behavior, and Immunity},
  year={1995},
  volume={9},
  pages={315-330}
}
  • A. R. Glabinski, M. Tani, +2 authors R. M. Ransohoff
  • Published 1995 in Brain, Behavior, and Immunity
  • DOI:10.1006/brbi.1995.1030
Central nervous system (CNS) expression of two chemokine mRNAs, encoding monocyte chemoattractant protein-1 (MCP-1) and IFN-gamma-inducible protein (IP-10), was previously shown to be closely related to the onset of clinical signs of murine experimental autoimmune encephalomyelitis (EAE). Chemokine mRNAs accumulated in a striking, transient burst within astrocytes, near inflammatory leukocyte infiltrates. It remained unclear if chemokines functioned to initiate leukocyte entry into CNS tissues… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…