Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.

@article{Egecioglu2009CentralNS,
  title={Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.},
  author={Emil Egecioglu and Karolina Ploj and Xiufeng Xu and Mikael Bjursell and Nicolas Salom{\'e} and Niklas Andersson and C Ohlsson and Magdalena Taube and Caroline Hansson and Mohammad Bohlooly-Y and David G A Morgan and Suzanne L. Dickson},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={297 3},
  pages={E708-16}
}
To investigate the role of the central neuromedin U (NMU) signaling system in body weight and energy balance regulation, we examined the effects of long-term intracerebroventricular (icv) infusion of NMU in C57Bl/6 mice and in mice lacking the gene encoding NMU receptor 2. In diet-induced obese male and female C57BL/6 mice, icv infusion of NMU (8 microg x… CONTINUE READING