Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine

@article{Hsieh2004CentralMR,
  title={Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine},
  author={Gin C. Hsieh and Peter R. Hollingsworth and Brenda R Martino and Renjie Chang and Marc A Terranova and Alyssa B. O'Neill and James J. Lynch and Robert B. Moreland and D L Donnelly-roberts and Teodozyi Kolasa and Joseph P. Mikusa and Jill M McVey and Kennan Marsh and James P. Sullivan and Jorge D. Brioni},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={308},
  pages={330 - 338}
}
Apomorphine has been used as a pharmacological probe of dopaminergic receptors in a variety of central nervous system disorders. The utility of apomorphine as an agent for the treatment of erectile dysfunction has also been demonstrated clinically. Apomorphine is a nonselective dopaminergic receptor agonist with potent binding affinity (Ki) of 101, 32, 26, 2.6, and 10 nM for D1, D2, D3, D4, and D5, respectively. When administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v… 

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