Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
@article{Hsieh2004CentralMR, title={Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine}, author={Gin C. Hsieh and Peter R. Hollingsworth and Brenda R Martino and Renjie Chang and Marc A Terranova and Alyssa B. O'Neill and James J. Lynch and Robert B. Moreland and D L Donnelly-roberts and Teodozyi Kolasa and Joseph P. Mikusa and Jill M McVey and Kennan Marsh and James P. Sullivan and Jorge D. Brioni}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2004}, volume={308}, pages={330 - 338} }
Apomorphine has been used as a pharmacological probe of dopaminergic receptors in a variety of central nervous system disorders. The utility of apomorphine as an agent for the treatment of erectile dysfunction has also been demonstrated clinically. Apomorphine is a nonselective dopaminergic receptor agonist with potent binding affinity (Ki) of 101, 32, 26, 2.6, and 10 nM for D1, D2, D3, D4, and D5, respectively. When administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v…
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References
SHOWING 1-10 OF 57 REFERENCES
Dopaminergic neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat.
- Biology, MedicineThe Journal of urology
- 1999
It is demonstrated that application of apomorphine to the paraventricular nucleus of hypothalamus elicited penile erection in the rat and indicates that PVN may be involved in the central regulation of apomorphicine-induced penile implantation in theRat.
Apomorphine-induced penile erection and yawning: site of action in brain
- Biology, PsychologyBrain Research
- 1987
Effect of apomorphine on intracavernous pressure and blood pressure in conscious, spinalized rats
- Biology, MedicineInternational Journal of Impotence Research
- 2002
The results suggest that both in normal rats, and in rats with spinal cord injury, apomorphine given s.c., can produce erection, which supports the use of apomorphicine for treatment of erectile dysfunction in paraplegia patients, however, due consideration should be given to possible decreases in blood pressure.
Dopamine Agonists Increase Nitric Oxide Production in the Paraventricular Nucleus of the Hypothalamus: Correlation with Penile Erection and Yawning
- BiologyThe European journal of neuroscience
- 1996
It is inferred that dopamine agonists induce penile erection and yawning by acting on D2 receptors that increase nitric oxide synthase activity in the cell bodies of paraventricular oxytocinergic neurons projecting to extra‐hypothalamic brain areas.
Brain somatostatin depletion by cysteamine attenuates the penile erection induced by serotonergic and dopaminergic, but not by cholinergic, activation in rats
- Biology, MedicineBrain Research
- 1996
Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine
- Biology, PsychologyNeuroscience & Biobehavioral Reviews
- 2000
Dopamine D1 receptor agonists induce penile erections in rats.
- Biology, ChemistryEuropean journal of pharmacology
- 2003
Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats
- BiologyBrain Research
- 1987
Spinal proerectile effect of apomorphine in the anesthetized rat
- Biology, MedicineInternational Journal of Impotence Research
- 2001
The existence of a spinal site of action for apomorphine which may participate to generation of erection and exerts a facilitator effect on erection of supraspinal origin is suggested.
Pharmacology of penile erection.
- Biology, MedicinePharmacological reviews
- 2001
Dopamine receptors in central nervous centers participating in the initiation of erection have been targeted for the treatment of ED, and Apomorphine, administered sublingually, is the first of such drugs.