Central Leptin and Cholecystokinin in Gastroprotection against Ethanol-Induced Damage

  title={Central Leptin and Cholecystokinin in Gastroprotection against Ethanol-Induced Damage},
  author={Tomasz Brzozowski and Peter Ch. Konturek and Stanisław Jan Konturek and Piotr Pierzchalski and Władysław Bielański and Robert Pajdo and Danuta Drozdowicz and Sławomir Kwiecień and Eckhart G. Hahn},
  pages={126 - 142}
Background: Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal integrity. Aims: In this study we compared the effects of leptin and CCK-8 applied intracerebroventricularly (i.c.v.) on gastric secretion and gastric mucosal lesions induced by… 

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