Central Dogma of Molecular Biology

  title={Central Dogma of Molecular Biology},
  author={Francis H. C. Crick},
  • F. Crick
  • Published 8 August 1970
  • Biology
  • Nature
The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred from protein to either protein or nucleic acid. 

Editing the flow of information

The central dogma of molecular biology states that genetic information stored in DNA is transcribed and subsequently translated into proteins. The information should thereby be copied from DNA into...

Computational Models in Non-Coding RNA and Human Disease

The central dogma of molecular biology has told that DNA sequences encode proteins through RNAs, which function as an information intermediary, and this paper presents evidence that RNAs can be passed between DNA and RNA.

Reimagining the Power of Nucleic Acids as Therapeutic and Diagnostic Agents

The central dogma of molecular biology proposes that in a typical cell, the flow of genetic information proceeds from DNA to RNA to polypeptide [...]

Molecular Biology: The Central Dogma

Although proteins are essential components of all aspects of cell structure and function, they are not sufficient for their own propagation. Instead, the information necessary to specify each

Introduction to Molecular Biology

The physicochemical properties of cellular components and their functions in nerve-impulse conduction, vision, membrane transport, and molecular genetics constitute some of the topics of molecular biology.

The evolution of central dogma of molecular biology: a logic-based dynamic approach

This review renewed and re-expressed the central dogma as a mathematical model and showed that the enhancement of the complexity kept pace with the gaining robustness.

Reverse Transcription and the Central Dogma

The Central Dogma of molecular biology which postulates the unidirectional transmission of genetic specifications for protein biosynthesis was enunciated by Crick (1958) who proposed explicitly that

Protein Interactions from the Molecular to the Domain Level

The basic unit of life is the cell, from single-cell bacteria to the largest creatures on the planet, which contains the blueprint for proteins.

Molecular Phylogenetics and the Perennial Problem of Homology

The concept of homology has a long history, during much of which the issue has been how to reconcile similarity and common descent when these are not coextensive. Although thinking molecular



Genes and Hereditary Characteristics

This appraisal of ideas about genetic determination is based on Dr Hershey's report in the sixty-eighth Year Book of the Carnegie Institution of Washington, issued last February.

The Chemical Basis of Inheritance

A refutation of Dr Barry Commoner's claim that the Watson–Crick theory fails to explain the chemical basis of inheritance.

Nature of the Scrapie Agent

It is suggested that scrapie can best be considered to arise from a replicable change in the structural pattern of a commonly occurring unit membrane and three possible mechanisms for its self-replication are proposed.

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template, apparently the classical process of information transfer from DNA to RNA can be inverted.

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

Viral RNA-dependent DNA Polymerase: RNA- dependent DNA polymerase in Virions of Rous Sarcoma Virus and its role in cell reprograming is studied.

Denatured DNA as a direct template for in vitro protein synthesis.

  • B. MccarthyJ. Holland
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1965
It will be shown below that streptomecin, neomycin, and kanamycin can greatly enhance the ability of single-stranded DNA from every source tested to stimulate protein synthesis by an E. coli cell-free system.

Failure of the Watson–Crick Theory as a Chemical Explanation of Inheritance

In reply to recent criticism Professor Commoner discusses current evidence in support of his conclusion that the Watson–Crick theory is an inadequate explanation of inheritance.

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary

Institute of Cancer Research , Columbia University, and Colle:e of Physicians and Surgeons

  • Institute of Cancer Research , Columbia University, and Colle:e of Physicians and Surgeons