Central Dogma of Molecular Biology

@article{Crick1970CentralDO,
  title={Central Dogma of Molecular Biology},
  author={Francis H. C. Crick},
  journal={Nature},
  year={1970},
  volume={227},
  pages={561-563}
}
  • F. Crick
  • Published 8 August 1970
  • Medicine, Biology
  • Nature
The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred from protein to either protein or nucleic acid. 
Editing the flow of information
The central dogma of molecular biology states that genetic information stored in DNA is transcribed and subsequently translated into proteins. The information should thereby be copied from DNA into...
Computational Models in Non-Coding RNA and Human Disease
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The central dogma of molecular biology has told that DNA sequences encode proteins through RNAs, which function as an information intermediary, and this paper presents evidence that RNAs can be passed between DNA and RNA. Expand
Reimagining the Power of Nucleic Acids as Therapeutic and Diagnostic Agents
The central dogma of molecular biology proposes that in a typical cell, the flow of genetic information proceeds from DNA to RNA to polypeptide [...]
Molecular Biology: The Central Dogma
Although proteins are essential components of all aspects of cell structure and function, they are not sufficient for their own propagation. Instead, the information necessary to specify eachExpand
Introduction to Molecular Biology
The term molecular biology came into use around the middle of the 20th century. In its broadest meaning, molecular biology comprises the study of a variety of biological processes at the molecularExpand
1970 The Flow of Information
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Reverse Transcription and the Central Dogma
The Central Dogma of molecular biology which postulates the unidirectional transmission of genetic specifications for protein biosynthesis was enunciated by Crick (1958) who proposed explicitly thatExpand
Protein Interactions from the Molecular to the Domain Level
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The basic unit of life is the cell, from single-cell bacteria to the largest creatures on the planet, which contains the blueprint for proteins. Expand
Molecular Phylogenetics and the Perennial Problem of Homology
The concept of homology has a long history, during much of which the issue has been how to reconcile similarity and common descent when these are not coextensive. Although thinking molecularExpand
The Biological Foundations of Bioinformatics
Nucleic acids and proteins are two important classes of macromolecules that play crucial roles in nature and form the basis of all life. Deoxyribonucleic acid (DNA) is the carrier of geneticExpand
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References

SHOWING 1-10 OF 12 REFERENCES
Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses
Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementaryExpand
Genes and Hereditary Characteristics
This appraisal of ideas about genetic determination is based on Dr Hershey's report in the sixty-eighth Year Book of the Carnegie Institution of Washington, issued last February.
The Chemical Basis of Inheritance
A refutation of Dr Barry Commoner's claim that the Watson–Crick theory fails to explain the chemical basis of inheritance.
Nature of the Scrapie Agent
TLDR
It is suggested that scrapie can best be considered to arise from a replicable change in the structural pattern of a commonly occurring unit membrane and three possible mechanisms for its self-replication are proposed. Expand
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses
TLDR
Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template, apparently the classical process of information transfer from DNA to RNA can be inverted. Expand
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus
Denatured DNA as a direct template for in vitro protein synthesis.
  • B. Mccarthy, J. Holland
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1965
TLDR
It will be shown below that streptomecin, neomycin, and kanamycin can greatly enhance the ability of single-stranded DNA from every source tested to stimulate protein synthesis by an E. coli cell-free system. Expand
Failure of the Watson–Crick Theory as a Chemical Explanation of Inheritance
In reply to recent criticism Professor Commoner discusses current evidence in support of his conclusion that the Watson–Crick theory is an inadequate explanation of inheritance.
tains the rerenmccs to Dr 'l'emln's earlier work dating back to 1903 See al.so the brier accoun~ or Spiegelman's reccnt work 011 page 1202
  • tains the rerenmccs to Dr 'l'emln's earlier work dating back to 1903 See al.so the brier accoun~ or Spiegelman's reccnt work 011 page 1202
  • 1970
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