Central Dogma Reversed

  title={Central Dogma Reversed},
  • Published 1970
  • Medicine
  • Nature
Testing amino acid-codon affinity hypothesis using molecular docking
Molecular docking was used to investigate the ability of amino acids to bind to their corresponding anticodon compared to other codons and no correlation with genetic correspondence rules was observed suggesting a more subtle process, other than direct binding, to explain codon-amino-acid specificity. Expand
60 years ago, Francis Crick changed the logic of biology
  • M. Cobb
  • Biology, Medicine
  • PLoS biology
  • 2017
This essay explores the concepts Francis Crick developed in this influential lecture, including his prediction that the authors would study evolution by comparing sequences, which still frame how they understand life. Expand
Telomerase and retrotransposons: Reverse transcriptases that shaped genomes
“Two independent groups of investigators have found evidence of an enzyme… which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications… informationExpand
Theory of the Origin, Evolution, and Nature of Life
A theoretical framework that economically fits evidence accumulated from examinations of life and unifies the macrocosmic and microcosmic realms, validates predicted laws of nature, and solves the puzzle of the origin and evolution of cellular life in the universe. Expand
RNA in Brain Disease: No Longer Just "The Messenger in the Middle"
  • P. Nelson, J. Keller
  • Biology, Medicine
  • Journal of neuropathology and experimental neurology
  • 2007
An overview of new research highlighting functions for RNA that far surpass the "messenger in the middle" role and that identify RNA molecules as important agents in the human brain in health and in disease states is presented. Expand
Information theory, evolution and the origin of life
  • H. Yockey
  • Mathematics, Computer Science
  • Inf. Sci.
  • 2002
This chapter discusses the genetic information system, the central dogma of molecular biology, and the role of Haeckel's Urschleim in the origin of life. Expand