Central 5-HT4 receptors.

@article{Eglen1995Central5R,
  title={Central 5-HT4 receptors.},
  author={R. Eglen and E. Wong and A. Dumuis and J. Bockaert},
  journal={Trends in pharmacological sciences},
  year={1995},
  volume={16 11},
  pages={
          391-8
        }
}
Activation of the 5-HT4 receptor mediates widespread effects in central and peripheral nervous systems. Recent developments, such as the identification of novel, selective agonists and antagonists, as well the cloning of the receptor, have provided insights into the physiological role of the receptor. In this article, Richard Eglen and colleagues assess the emerging evidence relating to the function of the 5-HT4 receptor in the brain. The cerebral distribution of the receptor, along with… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus.
TLDR
The present results suggest the presence in the CA1 region of the hippocampus of a novel 5-HT receptor at which BRL 24924 functions as a selective antagonist and which is capable of mediating slow excitatory responses in central neurons. Expand
Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: comparison with other mammalian species.
TLDR
The ability of several standard compounds in displacing the radioligand was compatible with the labelling of 5-HT4 receptors, and correlation analysis showed no significant differences amongst data obtained for these compounds using human, calf and guinea-pig membranes. Expand
The 5-HT4 receptor: a place in the sun.
TLDR
Now that the unique identity of the 5-HT 4 receptor, which is positively linked to adenylyl cyclase, is established, the recent data that have contributed to its general acceptance are reviewed. Expand
Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat
TLDR
It is demonstrated that under the authors' experimental conditions, DA content reflects the neuronal origin of the neurotransmitter release and that the 5-HT4, but not the5-HT1, 5- HT2 or 5-ht3, receptor subtype is implicated, at least partially, in this effect. Expand
Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives.
TLDR
It is shown that 4-amino-5-chlor-2-methoxy-benzamide derivatives are agonists of 5-HT4 receptors in guinea pig hippocampal membranes, and their effects on the adenylate cyclase of these membranes are not additive with those of5-HT but are additive with Those of RU 24969, a typical 5- HT1 agonist. Expand
A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.
TLDR
The relatively low affinity of this hippocampal receptor for 5-CT, its stimulation by RU 28253 but not by RU 24969, and its previously reported pharmacological characteristics support the contention that this 5- HT receptor and the 5-HT receptor of mouse embryo colliculi neurons in primary culture present great homologies. Expand
Serotonin-facilitated dopamine release in vivo: pharmacological characterization.
TLDR
The receptor specificity of serotonin (5-HT) agonist-induced facilitation of dopamine (DA) release was assessed by using in vivo microdialysis and coperfusion of antagonists with agonists indicated involvement of 5-HT1 and 5- HT3 receptors and a lack of involvement of 6-methyl-5H-thiazolo-1-pyrimidin-5-one receptors. Expand
Agonist effects at putative central 5-HT4 receptors in rat hippocampus by R(+)- and S(−)-zacopride; no evidence for stereo-selectivity
TLDR
The EEG of halothane anaesthetized rats was recorded from an electrode implanted into the hippocampus, and the effects of R(+)- and S(-)-zacopride were inhibited by pretreatment with a high dose of ICS 205-930, which suggests the involvement of 5-HT4 receptors. Expand
The serotonin-4 receptor agonist cisapride and angiotensin-II exert additive effects on aldosterone secretion in normal man.
TLDR
The data indicate that in humans, 5-HT does not potentiate the stimulatory effect of Ang II on aldosterone secretion, and provides further evidence that the action of 5- HT on glomerulosa cells is mediated through activation of5-HT4 receptors. Expand
Do human atrial 5-HT4 receptors mediate arrhythmias?
  • A. Kaumann
  • Chemistry, Medicine
  • Trends in pharmacological sciences
  • 1994
TLDR
5-HT may be involved in the genesis of atrial fibrillation and associated thromboembolic stroke and that both the arrhythmia and stroke could be prevented by inhibiting 5-HT4 receptors. Expand
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