Central, naloxone-reversible antinociception by diclofenac in the rat

@article{Bjrkman1990CentralNA,
  title={Central, naloxone-reversible antinociception by diclofenac in the rat},
  author={R L Bj{\"o}rkman and Jan Hedner and Thomas Hedner and Matts Henning},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1990},
  volume={342},
  pages={171-176}
}
The antinociceptive effect of subcutaneously (s. c.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered diclofenac was studied in a series of experiments employing the tail-flick (0.01–10.0 mg/kg body weight i. p., 1–50 μg i.c.v., 1–10 μg i.t.) and hotplate (0.01–50 mg/kg body weight i. p., 1– 50 μg i. c. v., 1–10 μg i. t.) models… CONTINUE READING