Centenarians, but not octogenarians, up-regulate the expression of microRNAs

@inproceedings{Serna2012CentenariansBN,
  title={Centenarians, but not octogenarians, up-regulate the expression of microRNAs},
  author={Eva Salazar Serna and Juan Pablo Gambini and Consuelo Borr{\'a}s and Kheira Mohammed and Angel Belenguer and Paula Hidalgo Sanchis and Juan Antonio Avellana and Leocadio Rodriguez-Ma{\~n}as and J. Vi{\~n}a},
  booktitle={Scientific reports},
  year={2012}
}
Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations in small non-coding RNA expression. We report the first comparison of microRNAs expression profiles in mononuclear cells from centenarians, octogenarians and young individuals… CONTINUE READING
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